Fig. 8 | Laboratory Investigation

Fig. 8

From: Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Fig. 8

GW-induced endothelial fibrosis inhibition decreases pro-inflammatory cytokines secretion in 72-h endotoxemic rats. Plasma levels of TNF-α (a), IL-1β (b), IL-6 (c), IL-12 (d), IL-4 (e), and IL-10 (f) were measured at 12, 24, 48, 72 h, in vehicle-treated/saline-treated rats (open bars, N = 8), vehicle-treated/endotoxemic rats (dashed bars, N = 8), GW-treated/endotoxemic rats (closed bars, N = 8), and GW-treated/saline-treated rats (dark gray bars, N = 8). GW-788388 was administrated by gavage (5 mg/kg a day) 24 h before and during 72-h endotoxemia. Values are expressed as the mean ± SD. *p < 0.05, **p < 0.01, assessed by one-way ANOVA (Kruskal–Wallis) and Dunn’s post-test

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