Fig. 2 | Laboratory Investigation

Fig. 2

From: N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements

Fig. 2

MATR3:YFP lacking RRM1 or RRM2 displays a greater tendency towards formation of spherical droplet-like intranuclear structures. Mouse C2C12 cells were grown on glass coverslips and transiently transfected with pEF.Bos vectors encoding WT MATR3:YFP lacking RRM1 (a−d) or RRM2 (e−h). At 24 h posttransfection, the cells were fixed and imaged with an Olympus epifluorescence microscope (×40 original magnification). The images shown are representative of images seen in three independent transfections, viewing 20−40 cells on each cover slip

Back to article page