Table 2 Sequencing metrics for MinION datasets

Case number	Total raw reads	Total alignment-ready reads^a	Read length (bp)^a		Read Quality (bp)^a		Mapped reads (%)	Aligned bases	Equivalent genome coverage	Number of reads mapping with target gene*	Reads ± 25 bp surrounding cleavage site (fold enrichment)
Case number	Total raw reads	Total alignment-ready reads^a	Mean	Median	Mean	Median	Mapped reads (%)	Aligned bases	Equivalent genome coverage	Number of reads mapping with target gene*	+ Strand guide	− Strand guide
1	274,500	27,886	3248	1590	8.9	9.2	97.53	88,356,565	0.029×	72	21 (700×)	15 (500×)
2	84,475	80,068	6067	3056	9.0	9.4	96.99	471,766,911	0.16×	436	67 (400×)	82 (500×)

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