Fig. 6: GTSE1 promotes the proliferation of prostate cancer cell via SP1/FOXM1 signaling pathway. | Laboratory Investigation

Fig. 6: GTSE1 promotes the proliferation of prostate cancer cell via SP1/FOXM1 signaling pathway.

From: GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway

Fig. 6

GTSE1 upregulated the expression of SP1 and enhanced the transcription of FOXM1, which ultimately promoted the proliferation of prostate cancer cell. However, the pro-proliferation effect of GTSE1 on prostate cancer could be significantly reversed by thiostrepton, a specific inhibitor of FOXM1.

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