Fig. 1: Hemoglobin is oxidized in ruptured atherosclerotic lesions, generating ferryl hemoglobin. | Laboratory Investigation

Fig. 1: Hemoglobin is oxidized in ruptured atherosclerotic lesions, generating ferryl hemoglobin.

From: Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

Fig. 1

Macroscopic images (a), histopathological analysis with hematoxylin and eosin (H&E) staining and immunohistological analysis with anti-hemoglobin (Hb) antibody of the human carotid artery: healthy arterial intima, atheromatous lesion, and complicated plaque with hemorrhage (b). Spectral analysis of hemoglobin (Hb), ferryl hemoglobin (FHb), and complicated plaque (Comp); the percentage of oxidized hemoglobin was calculated (c). Representative western blot of the human carotid artery using anti-Hb antibody (n = 3) (d). The results are shown as the mean values ± SEMs of the experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page