Fig. 2: Effect of TRPV4 pharmacological inhibition on PAR1-induced vascular hyperpermeability. | Laboratory Investigation

Fig. 2: Effect of TRPV4 pharmacological inhibition on PAR1-induced vascular hyperpermeability.

From: The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Fig. 2

Evans Blue retention measured in regions involved in the airways (a) or upper GI tract and jejunum (b). Animals were treated with vehicle alone, HC06 (10 mg/kg) with Vehicle (0.9% saline) or HC06 with TFLLR PAR1 agonist peptide (3 µmol/kg). Each data point represents a measurement from an individual animal, column graphs represent mean ± s.e.m., n = 6–11. *, #p < 0.05; **, ##p < 0.01; ***, ###p < 0.001; ****, ####p < 0.0001; two-way ANOVA with Sidak’s multiple comparisons test; relative to vehicle only control (*) or vehicle + TFLLR treatment (#).

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