Fig. 2: Effects on hepatic inflammation and fibrosis by ethanol in WT and FXRInt−/− mice. | Laboratory Investigation

Fig. 2: Effects on hepatic inflammation and fibrosis by ethanol in WT and FXRInt−/− mice.

From: Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency

Fig. 2

a Relative mRNA levels of genes involved in inflammation; b representative Masson’s trichrome staining of the livers (×200); solid triangle indicating the collagen stained blue; c IHC and semiquantification of YM1 positive cells in the livers (×200); d relative mRNA levels of fibrogenic genes. Values are presented as mean ± SD (n = 6, 10, 5, and 10 mice/group for WT/Veh, WT/EtOH, FXRInt−/−/Veh, and FXRInt−/−/EtOH, respectively). An asterisk (*) indicates statistical significance (p < 0.05) of ethanol treatment compared with vehicle (Veh) control group in the same strain. A hash symbol (#) indicates statistical significance between WT and FXRInt−/− mice (p < 0.05) with the same treatment. The scale bars show 50 μm for ×200 magnification.

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