Fig. 3: Expression of genes involved in BA homeostasis and regulating lipid homeostasis.
From: Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency
a Relative liver mRNA levels of genes involved in BA homeostasis; b relative intestinal mRNA levels of genes involved in BA homeostasis; c relative hepatic mRNA levels of genes involved in lipid metabolism, including fatty acid uptake, fatty acid synthesis, fatty acid β-oxidation, and VLDL secretion. Values are presented as mean ± SD (n = 6, 10, 5, and 10 mice/group for WT/Veh, WT/EtOH, FXRInt−/−/Veh, and FXRInt−/−/EtOH, respectively). An asterisk (*) indicates statistical significance (p < 0.05) of ethanol treatment compared with vehicle (Veh) control group in the same strain. A hash symbol (#) indicates statistical significance between WT and FXRInt−/− mice (p < 0.05) with the same treatment.
