Fig. 4: Hepatic expression of genes in ethanol metabolism and oxidative stress.
From: Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency
a Relative hepatic mRNA levels of Adh1, Aldh1 and Catalase; b representative immunoblots of liver CYP2E1 protein levels. Densitometric values were calculated and normalized with internal loading control, β-actin, and represented within the bar graphs; c relative hepatic mRNA levels of Nqo1, Gsta3, and Gclc. Values are presented as mean ± SD (n = 6, 10, 5, and 10 mice/group for WT/Veh, WT/EtOH, FXRInt−/−/Veh, and FXRInt−/−/EtOH, respectively). An asterisk (*) indicates statistical significance (p < 0.05) of ethanol treatment compared with vehicle (Veh) control group in the same strain. A hash symbol (#) indicates statistical significance between WT and FXRInt−/− mice (p < 0.05) with the same treatment.
