Fig. 1: Triple whammy induces overt AKI, whereas double and single treatments do not.
From: Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury
Evolution of plasma creatinine concentration (a), creatinine clearance (as an estimation of glomerular filtration rate) at day 6 (b), and urinary protein excretion at day 6 (c). The evolution of c and d is detailed in Supplementary Fig. 1. Data represent the mean ± SEM of n = 6 (C), 3 (I), 3 (T), 3 (F), 14 (I + T), 14 (I + F), 14 (T + F), 29 (I + T + F), 7 (G). In a, the two-way ANOVA test was used. Within the same group: *p < 0.05 versus basal, and day 0. @p < 0.05 vs day 2. $p < 0.05 vs day 4. Within the same day: &p < 0.05 vs control, I, T and F. #p < 0.05 versus, I + T, I + F, and T + F. In b and c, the Kruskal–Wallis test was used. &p < 0.05 vs control. *p < 0.05 vs F. #p < 0.05 vs T + F. $p < 0.05 vs G. F furosemide, G gentamicin, I ibuprofen, T trandolapril.
