Table 1 Description and characteristics of the experimental groups.
From: Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury
Group | Description | Treatment | n | |
|---|---|---|---|---|
No. | Acronym | |||
1 | C | Control | 0.9% saline solution i.p during 6 days | 6 |
2 | I | Ibuprofen, single treatment | Ibuprofen (400 mg/kg/day) v.o during 10 days and saline solution (0.9%) i.p during the last 6 days | 3 |
3 | T | Trandolapril, single treatment | Trandolapril (0.7 mg/kg/day) v.o during 10 days and saline solution (0.9%) i.p during the last 6 days | 3 |
4 | F | Furosemide, single treatment | Drinking water without any drug during 10 days and furosemide (20 mg/kg/day) i.p during the last 6 days | 3 |
5 | I + T | Ibuprofen + Trandolapril, double treatment | Ibuprofen (400 mg/kg/day) v.o plus trandolapril (0.7 mg/kg/day) v.o during 10 days and saline solution (0.9%) i.p during the last 6 days | 13 |
6 | I + F | Ibuprofen + Furosemide, double treatment | Ibuprofen (400 mg/kg/day) v.o during 10 days and furosemide (20 mg/kg/day) i.p during the last 6 days | 13 |
7 | T + F | Trandolapril + Furosemide, double treatment | Trandolapril (0.7 mg/kg/day) v.o during 10 days and furosemide (20 mg/kg/day) i.p during the last 6 days | 13 |
8 | I + T + F | Ibuprofen + Trandolapril + Furosemide, triple treatment | Ibuprofen (400 mg/kg/day) v.o plus trandolapril (0.7 mg/kg/day) v.o during 10 days and furosemide (20 mg/kg/day) i.p during the last 6 days | 30 |
9 | G | Gentamicin, single treatment, as an acute tubular necrosis (ATN) model | Gentamicin (150 mg/kg/day) i.p. during 6 days (n = 3) | 3 |
10 | M | Minoxidil, single treatment, as a model of BP reduction without interference on COX and RAS pathways | Minoxidil (15 mg/kg/day) v.o during 4 days (n = 3) | 3 |
11 | H + M | Hydralazine + Minoxidil, double treatment, as a model of BP reduction without interference on COX and RAS pathways | Hydralazine (20 mg/kg/day) v.o and minoxidil (15 mg/kg/day) v.o during 4 days (n = 3) | 3 |
