Fig. 2: Newborn CF pig gallbladder tissue lack CFTR-mediated anion transport.
From: Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model
a Representative traces from non-CF (blue) and CF (red) freshly excised newborn pig gallbladders mounted in Ussing chambers for electrophysiological studies. The following agents were added sequentially: apical 10 μM forskolin/100 μM IBMX (F&I), apical 100 μM GlyH-101, apical 100 μM DIDS, and basolateral 100 μM bumetanide (Bumet). b Changes in Isc (ΔIsc) values from freshly excised gallbladder tissue from five non-CF and three CF animals. Bars represent mean ± SEM. Asterisk (*) indicates p < 0.05.
