Fig. 2: PDX engraftment is associated with a subtype of lung squamous cell carcinoma. | Laboratory Investigation

Fig. 2: PDX engraftment is associated with a subtype of lung squamous cell carcinoma.

From: Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma

Fig. 2

A The patient-derived and PDX tumors in the non-engrafting (NEG) and engrafting (EG) groups were classified in relation to the subtypes of lung squamous cell carcinoma (LUSC) based on RNA sequencing data using GEPIA2. B-C Six cases of primary LUSC were subjected to immunohistochemistry (IHC) to distinguish the subtypes using the following marker proteins: p40, a marker of lung squamous cell carcinoma; TTF1, a marker of lung adenocarcinoma; CK7, a marker of the secretory subtype; p63, a marker of the classical subtype: S100, a marker of the basal subtype. All tissues were positive for p40, negative for TTF1, and negative for S100.

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