Fig. 4: PDX engraftment-associated genes show links to various cellular pathways. | Laboratory Investigation

Fig. 4: PDX engraftment-associated genes show links to various cellular pathways.

From: Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma

Fig. 4

A Cellular proliferation-associated genes (n = 1997) were identified by biological process analysis of the Gene Ontology (GO) database. Among the 295 selected genes detected by RNA sequencing, 92 PDX engraftment-associated genes were filtered with genes that showed a difference in expression of more than double between the non-engrafting (NEG) and engrafting (EG) groups. Two of EG-associated genes (B) and 9 of NEG-associated genes (D, F) belonged to cellular proliferation pathways in the GO biological process. B–J EG-associated gene (n = 8) were limited (B, C), whereas representative NEG-associated genes included signal transduction-related genes (D, E) and immune system-related genes (F, J). The representative immune system-related genes were divided into those involved in the common pathway (innate and adaptive immune systems) (G), innate immune system (H), adaptive immune systems (I), and cytokine signaling pathway (J). All asterisks indicate a P value < 0.05 by two-tailed Student’s t test.

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