Fig. 5: PDX engraftment is associated with tumor-infiltrating immune cells in CD19+ lymph follicles or CD23+ secondary lymph follicles. | Laboratory Investigation

Fig. 5: PDX engraftment is associated with tumor-infiltrating immune cells in CD19+ lymph follicles or CD23+ secondary lymph follicles.

From: Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma

Fig. 5

A, B Immunohistochemistry (IHC) was performed on patient-derived tumors in the non-engrafting (NEG) and engrafting (EG) groups using anti-CD19 and anti-CD23. A Lung alveoli and bronchiole were used as internal negative controls and tonsil as a positive control for CD19 and CD23 IHC. B Representative patient-derived tumors in the NEG group detected positivity of tumor-infiltrating immune cells in CD19+ lymph follicles and CD23+ secondary lymph follicles, whereas those in the EG group were mostly negative or showed single cell staining pattern. C The numbers of CD19+ lymph follicles and CD23+ secondary lymph follicles were counted, and the results for each specimen were presented as a grayscale heatmap.

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