Fig. 1: Location of MET gene alterations inducing exon 14 skipping. | Laboratory Investigation

Fig. 1: Location of MET gene alterations inducing exon 14 skipping.

From: An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology

Fig. 1

MET exon 14 skipping is caused by mutations at splice sites flanking this exon. It consists of point mutations or indels which can be located in introns, quite far from exon 14 and therefore difficult to detect. The advantage of assays using mRNA rather than DNA is that they detect directly the consequence of the alteration, and therefore can ascertain its biological impact without having to predict the effect according to previous reports or in silico. This figure is adapted from [34] and [50].

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