Table 3 Clinical, histological and molecular data of the ALK, ROS1 or RET translocated cases.
Case | Sex | Age | Sample | Location | Histology | Tumor cells % | Routine IHC / FISH | LD-RT-PCR | 5′ transcript | 3′ transcript |
|---|---|---|---|---|---|---|---|---|---|---|
ALK-A | M | 86 | RS | L | ADC | 50–100 | +/+ | + | EML4 exon 2 | ALK exon 20 |
ALK-B | M | 65 | RS | L | ADC | 25–50 | +/+ | − | EML4 exon 13 | ALK exon 20 |
ALK-C | F | 46 | BB | L | ADC | 15–25 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-D | M | 72 | BB | L | ADC | 5–15 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-E | F | 54 | RS | L | ADC | 25–50 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-F | M | 61 | BB | L | ADC | 25–50 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-G | F | 86 | BB | L | ADC | 15–25 | +/+ | + | EML4 exon 6 | ALK exon 20 |
ALK-H | F | 28 | SR | P | ADC | 15–25 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-I | M | 77 | BB | L | ADC | 15–25 | +/+ | + | EML4 exon 17 | ALK exon 20 |
ALK-J | M | 66 | BB | L | ADC | 15–25 | +/+ | + | EML4 exon 6 | ALK exon 20 |
ALK-K | F | 83 | RS | L | ADC | 50–100 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-L | M | 75 | RS | L | ADC | 0–5 | +/+ | + | EML4 exon 6 | ALK exon 20 |
ALK-M | M | 71 | BB | L | ADC | 15–25 | +/+ | + | HIP1 exon 21 | ALK exon 20 |
ALK-N | M | 68 | RS | L | ADC | 50–100 | +/+ | + | EML4 exon 18 | ALK exon 20 |
ALK-O | F | 44 | SR | LN | ADC | 25–50 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-P | F | 44 | RS | L | ADC | 25–50 | +/+ | + | EML4 exon 13 | ALK exon 20 |
ALK-Q | M | 64 | SR | P | ADC | 15–25 | +/+ | − | EML4 exon 7 | ALK exon 20 |
ALK-R | F | 68 | RS | L | ADC | 25–50 | +/+ | − | TRIM24 exon 12 | ALK exon 20 |
ROS1-A | F | 85 | RS | L | ADC | 50–100 | +/+ | + | EZR1 exon 10 | ROS1 exon 32 |
ROS1-B | F | 52 | SR | P | ADC | 50–100 | +/+ | + | CD74 exon 6 | ROS1 exon 34 |
ROS1-C | M | 97 | SR | P | ADC | 0–5 | +/+ | + | CD74 exon 6 | ROS1 exon 32 |
ROS1-D | F | 60 | SR | P | ADC | 15–25 | +/+ | + | SDC4 exon 2 | ROS1 exon 32 |
RET-A | F | 38 | SR | LN | ADC | 15–25 | NA | + | KIF5B exon 15 | RET exon 12 |
RET-B | M | 65 | BB | L | ADC | 15–25 | NA | + | CCDC6 exon 1 | RET exon 12 |
