Table 4 Clinical, histological and molecular data of the MET cases (either leading to exon 14 skipping or not).

Case	Sex	Age	Sample	Location	Histology	Tumor cells %	MET mutation	Routine process	LD-RT-PCR (exon 14 skipping only)
MET-A	F	67	BB	L	ADC	15–25	c.3082+1G>A	+	+
MET -B	F	71	RS	L	ADC	25–50	c.2942-2A>C	+	+
MET -C	M	68	C	LN	ADC	15–25	c.3082+1G>A	+	+
MET -D	M	78	RS	L	ADC	15–25	c.2942-3_2962del	+	+
MET -E	F	63	SB	P	ADC	15–25	c.3082G>C	+	+
MET -F	M	69	RS	L	ADC	50–100	c.2942-36_2942-14del	−	+
MET -G	M	70	RS	L	ADC	15–25	c.2942-36_2942-14del	−	+
MET -H	F	63	RS	L	ADC	15 to 25	c.2942-6_2942-2delinG	−	+
MET -I	F	63	RS	L	ADC	15 to 25	c.2942-6_2942-2delinG	−	+
MET -J	M	73	RS	L	ADC	50 to 100	c.3082+2T>C	−	+
MET -K	M	73	RS	L	ADC	15 to 25	c.3082+1G>A and c.252C>G	+	+
MET -L	F	72	BR	L	ADC	15 to 25	c.3061T>C	+	−
MET -M	M	67	BR	L	ADC	50 to 100	c.3308_3311delinsAAAA	+	−
MET -N	M	47	BR	L	ADC	15 to 25	c.25C>T	+	−
MET -O	F	84	BR	L	ADC	5 to 15	c.3890G>A	+	−
MET -P	M	71	BR	L	ADC	15 to 25	c.128T>C	+	−
MET -Q	M	74	BR	L	ADC	15 to 25	c.764G>T	+	−
MET -R	M	73	SB	L	ADC	15 to 25	c.467C>T	+	−
MET -S	F	76	RS	LN	ADC	15 to 25	c.974C>T	+	−

Cases MET-F and MET-G are from the same patient (the difference in age is due to a different sample time), as are cases MET-H and MET-I. Sample MET-K presented with two different MET mutations. Age is indicated in years. We report here all the MET mutations retrieved in our series, even those who are known not to lead to exon 14 skipping, which are useful to assess the specificity of LD-RT-PCR (no false positive result).
M male, F female, RS resection specimen, BB bronchial biopsy, C cytology, SB surgical biopsy, L lung, P pleura, LN lymph node, ADC adenocarcinoma, + positive, − negative, NA not applicable.

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