Fig. 1: Main distribution of DDAH-1 in basal nuclei, not brainstem.
From: DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage
a DDAH-1 was distributed mainly in cerebral cortex and basal nuclei, but less in brainstem and cerebellum. Representative images of immunofluorescence staining for DDAH-1 in basal nuclei, cortex, brainstem and cerebellum were shown. b DDAH-1−/− totally abolished DDAH-1 protein expression in brain. Nearly no expression of DDAH-1 was exhibited in DDAH-1−/− rats brain. Representative images of immunofluorescence staining for DDAH-1 in basal nuclei and cortex were shown. Data were representative of 3 independent experiments. Magnification = ×200. scale bar = 10 μm. DAPI = 2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride. DDAH-1 dimethylarginine dimethylamino hydrolase-1.
