Fig. 3: DDAH-1−/− rats showed aggravated ischemic damage after MCAO/R.
From: DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage
a Representative 24-h TTC staining of rat brain sections in DDAH-1−/− and WT rats under normal and ischemic conditions. The white-colored areas represented infarct region in these sections, and red-colored areas represented normal region. b–d Statistic analysis of NSS, infarct volume and its percentage. No significant difference was found in infarct volume and neurological behavior between WT and DDAH-1−/− rats under non-ischemic conditions (n = 5, p > 0.05). There were significant increases of NSS (n = 15, p = 0.039), infarct volume and percentage (n = 5, p < 0.001) in KO/M group. Data are presented as mean ± SD. nsp > 0.05, *p < 0.05, ***p < 0.001. KO knockout, WT wild-type, NSS neurological severity scores, MCAO/R middle cerebral artery occlusion/reperfusion.
