Fig. 1: Changes in terminal villi over gestation. | Laboratory Investigation

Fig. 1: Changes in terminal villi over gestation.

From: GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images

Fig. 1

In the early 3rd-trimester (1, 3), syncytiotrophoblast (ST) nuclei are evenly spaced. Capillaries (C) are distant from maternal blood, which bathes the villi. The stroma consists of loose extracellular matrix proteins with frequent macrophages and fibroblasts (brown and pink stars). At term (2, 4), the villi are smaller. Syncytiotrophoblast nuclei are gathered into knots (K), thinning the vasculosyncytial membrane. Capillaries are directly beneath the syncytiotrophoblast layer. Stroma is denser with lower cellularity.

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