Fig. 5: CBL reduces proliferation and enhances apoptosis of ALL cells via regulation of the IRF4/CDK6 axis. | Laboratory Investigation

Fig. 5: CBL reduces proliferation and enhances apoptosis of ALL cells via regulation of the IRF4/CDK6 axis.

From: microRNA-155-5p initiates childhood acute lymphoblastic leukemia by regulating the IRF4/CDK6/CBL axis

Fig. 5

A The statistical histogram denoting CDK6 overexpression and silencing efficiency, as determined by RT-qPCR. B The protein bands and statistical histogram denoting CBL, IRF4, and CDK6 protein expression after different treatments, as determined by the Western blot assay. C Line chart showing cell viability determined by the CCK-8 assay. D The apoptotic rate of cells and its statistical histogram, determined by flow cytometry. *p < 0.05 indicates significant difference. Each cell experiment was conducted three times independently.

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