Fig. 3: Molecular biological change in starvation (ST) and high fat (HF) pancreas tissues.

a co-localization of SIRT6 and SREBP1c via fluorescent double staining in pancreas; b–g levels of SIRT6, p-AMPKα/AMPKα, p-mTOR/mTOR, p-Raptor/Raptor, and Rheb in pancreas; h–j the abundance of Sirt6, Ampk, and mtor mRNA in pancreas. *Compared with the NC group, P < 0.05; #Compared with the ST group, P < 0.05. n = 8 per group.