Table 2 Exosome-derived noncoding RNA as biomarkers in liver diseases.

From: Clinical implications of exosome-derived noncoding RNAs in liver

Function	NcRNAs	Source	Expression	Model	Disease	Ref
Diagnosis	miR-let-7f	Serum	Up	Human、Mice	ALD	Eguchi et al.²²
	miR-29
	miR-340
	miR-192	Serum	Up	Human、Mice	ALD	Momen-Heravi et al.²³
	miR-30a	Serum	Up	Human、Mice	ALD	Momen-Heravi et al.²³
	miR-122	Serum	Up	Mice	ALD	Bala et al.²⁴
	miR-155	Serum	Up	Mice	ALD	Bala et al.²⁴
	miR-155	Serum	Up	Human、Mice	ALD	Babuta et al.²¹
	miR-192-5p	Serum/Cell culture supernatants (HepG2 and HepG2 2.2.15 hepatoma cell lines)	Up	Human	CHB	Arataki K et al.³¹; van der Ree et al.³²
	miR-193b-3p
	miR-194-5p
	miR-122
	miR-22
	lncR-H19	Serum	Up	Human	BA	Xiao et al.³⁹
	miR-16	Biliary	Up	Human	CCA	Li et al.⁴¹
	miR-486-3p
	miR-484
	miR-1274b
	miR-191
	miR-205-5p	CCA cell lines and normal human cholangiocyte cells	Up	Human	CCA	Kitdumrongthum et al.⁴²
	miR-200	CCA cell lines and normal human cholangiocyte cells	Up	Human	CCA	Kitdumrongthum et al.⁴²
	miR-122	Serum	Up	Mice	DILI	Bala et al.²⁴
	miR-155
	miR-146a
	miR-125b
	miR-122	Plasma	Up	Mice	DILI	Cho et al.³⁶
	miR-192
	miR-155
	miR-18a	Serum	Up	Human	HCC	Sohn et al.⁴³
	miR-221
	miR-222
	miR-224
	miR-101	Serum	Down	Human	HCC	Sohn et al.⁴³
	miR-106b
	miR-122
	miR-195
	miR-30e	Serum	Down	Human	HCC	Bhattacharya et al.⁵⁴
	miR-223	Serum	Down	Human	HCC	Bhattacharya et al.⁵⁴
	miR-10b	Serum	Up	Mice	HCC	Liu et al.⁵⁶
	miR-21	Serum	Up	Mice	HCC	Liu et al.⁵⁶
	miR-122	Serum	Down	Mice	HCC	Liu et al.⁵⁶
	miR-200a	Serum	Down	Mice	HCC	Liu et al.⁵⁶
	miR-665	Serum/Cell culture supernatants (MHCC97H, MHCC97L, LO2 and SMMC7721 cell lines)	Up	Mice	HCC	Qu et al.⁵⁷
	lncR-HEIH	Serum	Up	Human	HCC	Zhang et al.⁶⁷
Predicting poor Prognosis	miR-665	Serum/Cell culture supernatants(MHCC97H,MHCC97L,LO2 and SMMC7721 cell lines)	Up	Mice	HCC	Qu et al.⁵⁷
	miR-125b	Serum	Down	Human	HCC	Liu et al.⁵⁸
	miR-21	Serum	Up	Human	HCC	Lee et al.⁵⁹
	lncR-ATB	Serum	Up	Human	HCC	Lee et al.⁵⁹
	lncR-ENSG00000258332.1	Serum	Up	Human	HCC	Xu et al.⁶⁸
	linc00635	Serum	Up	Human	HCC	Xu et al.⁶⁸

ALD alcoholic liver disease, CHB chronic hepatitis B, BA biliary atresia, CCA cholangiocarcinoma, DILI drug-induced liver injury, HCC hepatocellular carcinoma.

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Table 2 Exosome-derived noncoding RNA as biomarkers in liver diseases.

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