Fig. 3: Distinct target staining and non-overlapping cross-reactivities of two CTLA-4 antibodies. | Laboratory Investigation

Fig. 3: Distinct target staining and non-overlapping cross-reactivities of two CTLA-4 antibodies.

From: Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

Fig. 3

The panels show for the antibody MSVA-152R a strong staining of a subset of lymphocytes in a Hodgkin’s lymphoma (A), a strong cytoplasmatic staining of an adrenocortical adenoma (B) absence of staining in a pheochromocytoma (C), and a staining of few lymphocytes in a hepatocellular carcinoma (D). For the antibody CAL49, an equally strong staining of the identical subset of lymphocytes in a Hodgkin’s lymphoma is seen (E), while staining is lacking in an adrenocortical adenoma (F), and a cytoplasmic staining occurs in a pheochromocytoma (G) and a hepatocellular carcinoma (H). The images (A–D) and (E–H) are from consecutive tissue sections and taken at 20x magnification.

Back to article page