Fig. 6: Correlation between SLUG and epithelial-mesenchymal transition marker expression in pleomorphic adenomas.
From: SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma
A Representative hematoxylin and eosin image of a pleomorphic adenoma containing ductal structures composed of luminal cells (red arrow heads) and myoepithelial cells (black arrows). B Myoepithelial cells show focal calponin 1 positivity. C SLUG expression was observed in neoplastic myoepithelial cells and stromal cells but not luminal cells. D Luminal cells exhibited strong membranous expression of E-cadherin, whereas myoepithelial cells exhibited a markedly reduced immunoreactivity for E-cadherin. E Luminal cells were completely negative for vimentin, whereas myoepithelial cells exhibited weak to moderate immunoreactivity for vimentin. Scale bar: 100 μm.
