Table 2 Multivariate Cox proportional hazard regression model of clinical and molecular features.
From: Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas
OS | PFS | |||
|---|---|---|---|---|
Variables | HR (95% CI) | p value | HR (95% CI) | p value |
Age | 1.042 (0.893–1.217) | 0.599 | 0.921 (0.795–1.066) | 0.270 |
Sex | ||||
Male | 1 | 0.779 | 1 | 0.071 |
Female | 0.848 (0.268–2.681) | 0.322 (0.094–1.103) | ||
Extent of resection | ||||
Total resection | 1 | 0.175 | 1 | 0.636 |
Non-total resection | 2.922 (0.620–13.773) | 1.616 (0.222–11.760) | ||
Chemotherapy | ||||
Yes | 1 | 0.003 | 1 | 0.134 |
No | 44.606 (3.780–526.323) | 0.122 (0.008–1.909) | ||
Radiotherapy | ||||
Yes | 1 | 0.004 | 1 | 0.277 |
No | 24.348 (2.699–219.625) | 4.312 (0.309–60.088) | ||
ATRX mutation | ||||
No | 1 | 0.255 | 1 | 0.344 |
Yes | 2.203 (0.566–8.570) | 2.012 (0.473–8.554) | ||
MMR genes mutation | ||||
No | 1 | 0.748 | 1 | 0.614 |
Yes | 0.786 (0.180–3.426) | 1.476 (0.324–6.719) | ||
TP53 mutation | ||||
No | 1 | 0.024 | 1 | 0.071 |
Yes | 5.936 (1.261–27.934) | 3.844 (0.891–16.578) | ||
