Fig. 2: Detection of SARS-CoV-2 sense strand RNA and spike protein in the myocardium. | Laboratory Investigation

Fig. 2: Detection of SARS-CoV-2 sense strand RNA and spike protein in the myocardium.

From: Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort

Fig. 2

Representative images of SARS-CoV-2 sense strand spike protein within the interstitium (E), within blood vessels (A), within dying cardiac myocytes (C), and within percolating myocardial adipose tissue (D). SARS-CoV-2 spike protein expression was detected in blood vessels (B) and inflammatory infiltrates regions (F), where lipofuscin was also detected in the cardiomyocytes. Graphical representation of SARS-CoV-2 spike protein expression (H) and replicative strand expression (G) in the hearts of 21 COVID-19 patients. Yellow arrows indicate regions of viral positivity.

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