Fig. 8: NOB reduces oxidative stress in RGCs at 2 weeks post-IOP elevation. | Laboratory Investigation

Fig. 8: NOB reduces oxidative stress in RGCs at 2 weeks post-IOP elevation.

From: Nobiletin protects retinal ganglion cells in models of ocular hypertension in vivo and hypoxia in vitro

Fig. 8

A Representative immunohistochemical staining of 8-OHdG in retinas from rats with vehicle or 10 μM NOB treatment. Black arrow shows positively stained cells. Scale bar, 50 μm. B Quantitative analysis of 8-OHdG-positive cells in the GCL. C–E Quantification of Nrf2, Keap1 and HO-1 mRNA. F Representative Western blot for total Nrf2 and HO-1. G, H Quantification of total Nrf2 and HO-1 Western blot normalized to β-actin. The results are shown as mean ± SD, n = 6. *P < 0.05, **P < 0.01 and ****P < 0.0001.

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