Table 2 Cytogenetic abnormalities among 1002 patients with primary myelofibrosis and corresponding comparisons of survival

From: Revised cytogenetic risk stratification in primary myelofibrosis: analysis based on 1002 informative patients

Specific abnormalities

Total abnormal N = 449

Survival comparison vs. Normal karyotype (N = 553) P value (HR; 95% CI)

Survival comparison vs. ‘Unfavorable’ category template (N = 38)a P value (HR; 95% CI)

Survival comparison vs. ‘VHR’ category template (N = 40)b P value (HR; 95% CI)

Sole 20q−

74

0.1 (1.3; 0.9–1.7)

0.02 (0.6; 0.4–0.9)

<0.001 (0.2; 0.1–0.3)

Sole 13q−

56

0.08 (0.7; 0.5–1.0)c

<0.001 (0.3; 0.2–0.6)

<0.001 (0.1; 0.06–0.2)

Sole +9

14

0.7 (0.9; 0.4–1.7)

0.02 (0.4; 0.2–0.8)

<0.001 (0.1; 0.04–0.3)

Sole sex chromosome abnormality, including -Y

19

0.6 (0.9; 0.5–1.4)

0.03 (0.5; 0.3–0.9)

<0.001 (0.1; 0.06–0.3)

Sole chromosome 1 translocations/duplications

21

0.7 (1.1; 0.7–1.9)

0.01 (0.4; 0.2–0.8)

<0.001 (0.1; 0.05–0.3)

Sole translocations not involving chromosome 1

25

0.03 (1.7; 1.1–2.6)

0.27 (0.7; 0.4–1.3)

<0.001 (0.2; 0.09–0.4)

Sole +8

26

<0.001 (2.2; 1.4–3.3)

–

<0.001 (0.4; 0.2–0.7)

Sole 7q−

12

0.009 (2.3; 1.2–4.3)

–

0.008 (0.4; 0.2–0.8)

Sole autosomal trisomies, other than +9 or +8

15

<0.001 (3.8; 2.1–6.6)

0.19 (1.6; 0.8–3.1)

0.12 (0.6; 0.3–1.1)

Sole abnormalities not otherwise classified

31

0.008 (1.7; 1.1–2.5)

0.33 (0.8; 0.5–1.3)

<0.001 (0.3; 0.2–0.5)

Two abnormalities without VHR abnormality

52

0.07 (1.3; 1.0–1.8)

0.05 (0.6; 0.4–1.0)

<0.001 (0.3; 0.2–0.4)

Single/multiple 5q− abnormalities

11

0.28 (1.5; 0.7–3.0)

0.3 (0.6; 0.3–1.5)

0.003 (0.2; 0.08–0.6)

Single/multiple monosomy 7 abnormalities

18

<0.001 (6.3; 3.8–10.4)

0.005 (2.5; 1.3–4.7)

—

Single/multiple 12p−/12p11.2 abnormalities

11

<0.001 (5.6; 2.9–10.5)

0.03 (2.2; 1.1–4.6)

—

Single/multiple 11q−/11q23 abnormalities

13

<0.001 (3.0; 1.7–5.3)

0.3 (1.4; 0.7–2.7)

0.2 (0.6; 0.3–1.3)

Single/multiple i(17q)/inv(3) abnormalities

11

<0.001 (6.6; 3.6–12.2)

0.008 (2.8; 1.3–6.0)

—

Monosomal karyotype without VHR abnormality

13

0.19 (1.5; 0.8–3.0)

0.38 (0.7; 0.3–1.5)

0.002 (0.2; 0.1–0.6)

Non-monosomal complex without VHR abnormality

27

0.02 (1.7; 1.1–2.6)

0.36 (0.8; 0.4–1.3)

<0.001 (0.3; 0.2–0.5)

  1. a Unfavorable risk category template included sole abnormalities of +8 or 7q−
  2. b Very high risk (VHR) category template included single or multiple abnormalities of −7, inv(3), i(17q) and 12p−/12p11.2
  3. c Trend favoring 13q−
  4. Bold indicates significant differences
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