Table 2 Prevalence of problems in distinct dimensions of EQ-5D, EQ-5D index, and EQ-VAS in MDS patients

	Mobility problem^a		Self-care problem^a		Usual activities problem^a		Pain/discomfort problem^a		Anxiety/depression problem^a		EQ-5D: index				EQ-5D: VAS
	%	p	%	p	%	p	%	p	%	p	Mean	SD	N	p	Mean	SD	N	p
Total	41.0		13.3		36.1		49.5		37.9		0.74	0.23	1683		69.6	20.1	1657
Sex		0.007		0.030		0.021		<0.001		<0.001				<0.001				0.005
Male	39.1		11.6		33.6		45.5		30.1		0.77	0.22	1035		70.70	20.02	1022
Female	44.0		16.0		40.0		55.9		50.3		0.69	0.23	648		67.83	20.19	635
Age group (years)		<0.001		<0.001		<0.001		<0.001		0.581				<0.001				<0.001
<60	18.5		2.7		26.6		31.5		40.8		0.80	0.22	184		76.65	19.35	185
60–75	33.0		8.5		29.1		43.5		35.9		0.78	0.21	705		72.72	19.95	694
75+	53.3		20.0		44.5		58.9		39.0		0.69	0.23	794		65.14	19.48	778
IPSS		0.083		0.057		0.899		0.005		0.884				0.845				0.298
Low risk	42.4		13.2		49.6		53.1		39.2		0.74	0.23	809		70.20	19.84	798
Intermediate risk	38.2		13.1		47.7		49.3		36.8		0.75	0.22	780		68.98	20.27	764
Low/int-1 no cytogenetics^b	51.6		16.1		64.5		44.7		36.6		0.70	0.23	93		69.34	21.40	94
IPSS-R		0.656		0.907		0.899		0.023		0.119				0.769				0.044
Very low risk	40.6		11.9		32.4		53.1		33.8		0.75	0.23	429		71.40	19.46	422
Low risk	40.8		13.0		36.6		49.3		38.9		0.73	0.23	645		69.05	20.38	637
Intermediate risk	42.4		14.4		36.5		44.7		42.9		0.73	0.22	340		68.29	20.76	333
High/very high risk	40.4		14.7		35.8		52.3		36.7		0.76	0.21	109		68.61	21.16	109
Unknown	40.6		15.0		43.1		48.8		35.0		0.74	0.22	160		70.49	18.57	156
MDS-CI		<0.001		<0.001		<0.001		<0.001		0.493				<0.001				<0.001
Low risk	33.9		10.1		31.6		44.5		37.3		0.76	0.22	1072		72.59	19.38	1053
Intermediate risk	51.8		18.4		42.8		57.2		38.4		0.70	0.23	523		64.92	20.09	518
High risk	63.6		22.7		50.0		64.8		42.0		0.67	0.25	88		61.26	21.76	86
Haemoglobin (g/dL)		<0.001		<0.001		<0.001		0.026		0.002				<0.001				<0.001
≥10	34.5		9.2		28.9		46.9		34.3		0.77	0.22	909		72.71	19.44	893
<10	49.2		18.3		45.0		53.2		42.4		0.70	0.23	765		65.79	20.31	755
Unknown	0.0		0.0		0.0		0.0		22.2		0.95	0.10	9		80.56	15.30	9
Red blood cell transfusion^c		<0.001		<0.001		<0.001		0.049		0.070				<0.001				<0.001
No	35.9		9.8		30.9		47.5		36.2		0.76	0.22	1160		71.74	19.56	1137
Yes	52.2		21.0		47.4		53.9		41.7		0.69	0.24	523		64.94	20.57	520

IPSS-R Revised International Prognostic Scoring System, MDS-CI myelodysplastic syndrome-comorbidity index. Bold numbers emphasize significant differences (p<0.05).
^a Problem: moderate or severe problems
^b Patients with cytogenetics failed or not available were included if the diagnosis of MDS was morphologically proven, with <5% bone marrow blasts and at most a single cytopenia according to the IPSS. Based on these criteria, exclusively IPPS low or int-1 patients were included in EUMDS
^c As assessed in the year prior to initial diagnosis

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Table 2 Prevalence of problems in distinct dimensions of EQ-5D, EQ-5D index, and EQ-VAS in MDS patients

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