Fig. 1
Frequencies of significantly (P < 0.01) differentially expressed genes (red denotes upregulated genes whereas green denotes downregulated genes) and their chromosomal locations in dup(1q)-positive pediatric HeH and t(1;19) cases. a Gene expression profiling (GEP) analysis of HeH cases w (n = 7)/wo (n = 46) gain of 1q revealed that 252 genes were differentially expressed between cases w/wo dup(1q): 196 (78%) were overexpressed (46 (23%) of which mapped to 1q) and 56 (22%) were underexpressed. b GEP analysis of t(1;19) cases w (n = 7)/wo (n = 7) gain of 1q showed that 424 genes were differentially expressed between the t(1;19) cases w/wo dup(1q): 242 (57%) were overexpressed (76 (31%) of which mapped to 1q) and 182 (43%) were underexpressed. In the cases with der(19)t(1;19), resulting in loss of distal 19p, 30 genes located on chromosome 19 were downregulated; 16 (53%) of these mapped to the 1.6 Mb region telomeric to the TCF3 gene at 19p13.3
