Table 1 In-frame fusion genes identified by RNA or DNA sequencing
From: Kinase domain activation through gene rearrangement in multiple myeloma
Sample | Disease state | Cytogenetic group | GEP70 risk group | Head gene | Head last exon | Tail gene | Tail first exon | In-frame | RNA-seq | RT-PCR | DNA-seq | ddPCR | Fusion gene function |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
35882 | SMM | t(4;14) | LR | TSPAN3 | 5 | ROS1 | 31 | Yes | Yes | Yes | NC | ND | Kinase |
38203 | NDMM | HRD | LR | ATM | 57 | DLG2 | 8 | Yes | No | ND | Yes | ND | Kinase |
35830 | NDMM | HRD | LR | TXNDC5 | 7 | MYC | 2 | Yes | Yes | ND | No | ND | TF |
37871 | NDMM | t(14;20) | LR | KANK1 | 7 | BRAF | 9 | Yes | No | ND | Yes | Yes | Kinase |
39882 | NDMM | t(4;14) | LR | SUB1 | 3 | WHSC1 | 5 | Yes | Yes | ND | NC | ND | |
40145 | NDMM | HRD | LR | MED15 | 1 | EP300 | 21 | Yes | ND | ND | Yes | ND | TF |
35711 | Treated | t(14;20) | HR | CDC6 | 9 | RARA | 3 | Yes | No | ND | Yes | ND | TF |
38740 | Treated | t(14;16) | HR | EML4 | 6 | ALK | 20 | Yes | Yes | Yes | Yes | Yes | Kinase |
15639 | Relapse | HRD | LR | SS18 | 5 | FLI1 | 4 | Yes | Yes | ND | NC | ND | TF |
10763 | Relapse | t(4;14) | LR | GTF2I | 4 | BRAF | 10 | Yes | Yes | ND | Yes | Yes | Kinase |
10763 | Relapse | t(4;14) | LR | AGK | 2 | BRAF | 8 | Yes | Yes | Yes | No | ND | Kinase |
10763 | Relapse | t(4;14) | LR | SNX29 | 1 | FGFR1 | 4 | Yes | Yes | ND | NC | ND | Kinase |
14122 | Relapse | HRD | LR | HNRNPA2B1 | 7 | NTRK3 | 14 | Yes | Yes | Yes | Yes | ND | Kinase |
21003 | Relapse | t(4;14) | HR | SUB1 | 3 | WHSC1 | 5 | Yes | Yes | ND | NC | ND | |
21058 | Relapse | t(11;14) | LR | AKT1 | 2 | MAPK14 | 11 | Yes | Yes | Yes | NC | ND | Kinase |
23130 | Relapse | HRD | LR | FOXO3 | 1 | MYC | 2 | Yes | Yes | ND | Yes | ND | TF |
27259 | Relapse | t(4;14) | HR | ESYT2 | 8 | BRAF | 9 | Yes | Yes | Yes | No | ND | Kinase |
38731 | Relapse | t(11;14) | HR | SLC5A5 | 7 | MYO18A | 8 | Yes | NC | ND | Yes | ND | |
39240 | Relapse | HRD | HR | TXNDC5 | 5 | MYC | 2 | Yes | Yes | ND | Yes | ND | TF |
39451 | Relapse | t(14;16) | HR | UBE2R2 | 3 | NTRK3 | 4 | Yes | Yes | Yes | NC | ND | Kinase |
15933 | Relapse | HRD | LR | ARHGAP27 | 6 | MAP3K14 | 5 | Yes | NC | ND | Yes | Yes | Kinase |
