Table 3 Concurrent Ras mutations and kinase fusion genes
From: Kinase domain activation through gene rearrangement in multiple myeloma
Fusion | Ras/Raf mutation (variant allele frequency) | IGH translocation | GEP70 risk |
|---|---|---|---|
AGK-BRAF a | None | t(4;14) | Low |
AKT1-MAPK14 | None | t(11;14) | Low |
ARHGAP27-MAP3K14 | KRAS (2%), NRAS (2%) | t(4;14) | High |
EML4-ALK | None | t(14;16) | High |
ESYT2-BRAF | None | t(4;14) | High |
GTF2I-BRAF a | KRAS (16%) | t(4;14) | Low |
HNRNPA2B1-NTRK3 | None | None | Low |
KANK1-BRAF | BRAF (2%) | t(14;20) | Low |
SNX29-FGFR1 a | None | t(4;14) | Low |
TSPAN3-ROS1 | BRAF (2%) | t(4;14) | High |
UBE2R2-NTRK3 | KRAS (42%) | t(14;16) | High |
ATM-DLG2 | None | None | Low |
