Table 2 Median OS between treatment arms (azacitidine vs CCR) for the most frequently mutated genes and genes involved in DNA methylation
Mutated gene | AZA | CCR | Stratified P Value |
|---|---|---|---|
Median OS, months (95%CI) | Median OS, months (95%CI) | ||
TP53 | 7.2 (3.9, 18.6) | 2.4 (1.5, 7.1) | 0.093 |
NRAS | 11.8 (7.7, NR) | 4.3 (2.3, NR) | 0.151 |
FLT3a | 5.4 (4.5, NR) | 6.4 (3.8, NR) | 0.271 |
TET2 | 9.6 (4.5, 13.5) | 11.1 (2.8, NR) | 0.036 |
IDH2 | 12.6 (4.4, NR) | 12.5 (5.6, NR) | 0.429 |
DNMT3A | 12.6 (7.0, 20.8) | 10.3 (3.8, NR) | 0.624 |
RUNX1 | 13.5 (8.8, NR) | 6.4 (3.8, NR) | 0.496 |
NPM1 | 7.3 (4.5, NR) | 12.5 (4.3, 17.6) | 0.726 |
ASXL1 | 18.7 (4.8, NR) | 14.6 (10.0, NR) | 0.643 |
STAG2 | 19.5 (11.9, NR) | 11.1 (5.1, NR) | 0.722 |
Any DNA methylation geneb | 11.1 (5.8, 15.4) | 12.5 (4.3,17.6) | 0.248 |
