Fig. 1 | Leukemia

Fig. 1

From: Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

Fig. 1

BCR analysis of TCL1 tumors. a Overall survival of seven primary TCL1 mice. b Schematic representation of the rearranged IgH and primers (arrows) used for PCR amplification and sequencing. c Pie charts show the frequency of specific CDR3 VDJ-H usage of seven primary TCL1 tumors. Segment size corresponds to relative occurrence of a particular VDJ-H sequence. The translated CDR3 amino acid sequences of the major and second major clone exceeding 0.3% frequency are depicted next to each segment. The remaining unmutated clones are summarized as miscellaneous unmutated BCRs (misc UM). Numbers in the center of the pie show the total number of sequences analyzed and numbers next to each CDR3 amino acid sequence indicates the percentage of the respective BCR clone

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