Fig. 5
Clonal and subclonal mutations in serially transplanted TCL1 tumors. a Heat map of all functional somatic mutations from three tumor lines found by WES. Color spectrum (white to red) corresponds to allelic frequencies of mutations. The total numbers of mutations are depicted as bar graphs next to the heat maps. b Graph shows survival of primary TCL1 mice and of tumor-transplant recipients (d: days). c Allelic frequencies of all functional mutations are shown as dot plots. d Allelic frequencies of all functional somatic mutations in the two analyzed transplant lines (D22 and C25) are shown as dot plots. Within each graph, the horizontal dotted lines indicate expected allelic frequencies of clonal heterozygous somatic mutations within the respective BCR-specific subclones (major clone: BCR #1; most frequent minor clone: BCR #2). Red dots represent mutated genes with allelic frequencies ≥ 75%. Yellow dots represent mutated genes that roughly correspond to clonal heterozygous somatic mutations within BCR-specific subclone #2. e Same analysis as (d) with primary TCL1 mice
