Table 1 OS and PFS according to mutational profiling

Female vs male

0.784 (0.36–1.708)

0.541

1.131 (0.578–2.213)

0.7189

R-IPSS

1.728 (1.011–2.955)

0.0455

1.51 (0.935–2.44)

0.0921

AGE

1.013 (0.973–1.054)

0.5431

1.02 (0.983–1.058)

0.3003

WBC

1.024 (0.987–1.064)

0.2069

1.027 (1.001–1.053)

0.0397

1.042 (1.012–1.073)

0.0062

KAR good vs poor

0.588 (0.266–1.301)

0.1901

0.603 (0.289–1.258)

0.1778

KAR intermediate vs poor

0.831 (0.276–2.499)

0.7415

0.815 (0.323–2.057)

0.6644

CR/PR/HI VS SD/PD

0.373 (0.175–0.796)

0.0108

0.344 (0.159–0.745)

0.0068

0.315 (0.158–0.628)

0.001

0.264 (0.129–0.541)

0.0003

HSCT

0.399 (0.177–0.900)

0.0267

0.473 (0.181–1.231)

0.1249

ASXL1 WT VS MUT

0.715 (0.348–1.472)

0.3628

0.89 (0.465–1.704)

0.7254

CEBPA WT VS MUT

4.155 (0.565–30.546)

0.1618

2.194 (0.527–9.133)

0.2802

CSF3R WT VS MUT

1.051 (0.367–3.01)

0.9256

0.838 (0.35–2.009)

0.692

DNMT3A WT VS MUT

0.774 (0.334–1.798)

0.5519

0.53 (0.257–1.092)

0.085

DNMT3A-R882 WT VS MUT

0.374 (0.125–1.121)

0.0790

0.339 (0.137–0.836)

0.0188

ETV6 WT VS MUT

0.636 (0.191–2.11)

0.4591

0.704 (0.249–1.993)

0.5084

EZH2 WT VS MUT

2.615 (0.356–19.223)

0.3448

0.923 (0.283–3.01)

0.8943

FLT3 WT VS MUT

1.116 (0.338–3.681)

0.8568

1.222 (0.375–3.979)

0.7398

IDH2 WT VS MUT

0.433 (0.151–1.247)

0.1209

0.496 (0.206–1.195)

0.1179

KRAS WT VS MUT

0.625 (0.189–2.067)

0.4411

0.862 (0.264–2.812)

0.8059

NRAS WT VS MUT

4.155 (0.563–30.638)

0.1624

1.577 (0.482–5.154)

0.4511

PTPN11 WT VS MUT

0.647 (0.225–1.859)

0.4185

0.682 (0.265–1.756)

0.4279

RUNX1 WT VS MUT

0.783 (0.358–1.709)

0.5388

0.919 (0.454–1.862)

0.8148

SETBP1 WT VS MUT

0.424 (0.201–0.893)

0.0239

0.420 (0.197–0.893)

0.0241

0.526 (0.268–1.031)

0.0612

SETBP1 SKI DOMAIN WT VS MUT

0.548 (0.190–1.582)

0.2662

0.523 (0.217–1.258)

0.1478

SF3B1 WT VS MUT

2.156 (0.514–9.036)

0.2934

1.781 (0.547–5.797)

0.3377

SRSF2 WT VS MUT

0.701 (0.287–1.712)

0.4352

0.514 (0.235–1.122)

0.0948

TET2 WT VS MUT

2.861 (1–8.188)

0.05

3.573 (1.185–10.773)

0.0237

1.793 (0.749–4.293)

0.19

TP53 WT VS MUT

0.38 (0.173–0.833)

0.0157

0.225 (0.094–0.537)

0.0008

0.463 (0.217–0.988)

0.0463

0.255 (0.111–0.585)

0.0013

U2AF1 WT VS MUT

0.392 (0.15–1.026)

0.0563

0.628 (0.245–1.614)

0.3342

ZRSF2 WT VS MUT

0.351 (0.138–0.893)

0.0279

0.426 (0.191–0.949)

0.0369