Fig. 3
From: NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia
a In situ 3D microscopy imaging of BM from primografts treated with NG2 antagonists. Representative images of large tissue volumes from the femoral diaphysis of transplanted mice treated with the vehicle (CTRL, left panels), or with 7.1 MoAb for 7 days (NG2 blockage, right panels). Large DAPI+ tissue regions depleted of huCD45+ cells are only observed in the BMs from mice treated with 7.1 MoAb. See also Supplementary Videos 1 and 2. b BM-MSCs protect MLLr-B-ALL cells against VxL chemotherapy (n = 2)
