Fig. 6
From: Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
Blockage of IFN-α or IFN-γ signaling restores the capacity of Stat5b−/− cells to form colonies. BM cells of wt, Stat5a−/− or Stat5b−/− mice were infected with a retrovirus encoding BCR/ABLp185 or BCR/ABLp210 and plated in growth factor-free methylcellulose. In addition 10 µg/ml antibodies (Ab) blocking a IFNAR1 or b IFN-γ or c combination of both (in total 10 µg/ml) were added (n = 4 per genotype). Levels of significance were calculated using Kruskal–Wallis test followed by Dunn’s test. Error bars represent means ± SEM. Right: representative pictures of CFA. IFN interferon, BM bone marrow, STAT signal transducers and activators of transcription, wt wild type, GSEA geneset enrichment analysis, CFA colony formation assays
