Fig. 1
The landscape of CN-LOH in B-ALL with whole or partial overrepresentation of chromosome 21. Identification (ID) numbers and chromosome 21 CNA are shown in the left hand columns for patients carrying regions of CN-LOH identified by analysis of SNP 6.0 arrays. Chromosome numbers are indicated in the top panel and CN-LOH status for each patient by box colour as shown in the key. For patients with an available remission sample, the origin was defined as somatic (not present in remission) or germline (present in remission) with iCN-LOH always identified as germline and all but one tCN-LOH defined as somatic. Chromosomal position of CN-LOH is indicated by; p (segment/s of the short arm), q (segment/s of the long arm) pq (segments of both short and long arms but not the whole chromosome), wc (whole chromosome). Multiple regions of CN-LOH that were predominantly interstitial, seen in patients 41 and 93, are indicative of consanguinity. tCN-LOH 6p (n = 2), 9p (n = 4) and 12q (n = 8) and wcCN-LOH 9 (n = 2) were recurrent
