Table 1 The incidence and location by cytogenetic band of tCN-LOH 12q and 6q identified in this study or previously published cases of B-ALL
Study | No. B-ALL patients | Patient ID | 12q CN-LOH | 6p CN-LOH | Chromosome 21 CN status |
|---|---|---|---|---|---|
Present study | 302 | 5 | 12q13.1-12qtel | iAMP21 | |
12 | 12q14-12qtel | OSA21 | |||
25 | 12q14-12qtel | iAMP21 | |||
28 | 12q12-12qtel | OSA21 | |||
44 | 12q11-12qtel | iAMP21 | |||
45 | 12q13.1-12qtel | iAMP21 | |||
78 | 12q13.1-12qtel | iAMP21 | |||
88 | 12q14-12qtel | iAMP21 | |||
71 | 6ptel-6p22.1 | iAMP21 | |||
85 | 6ptel-6p21.2 | iAMP21 | |||
Baughn 2015 [17] | 65 | Not reported | 12q24.12-q24.32 | iAMP21 | |
Kawamata 2008 [15] | 399 | Not reported | 12q? to 12qtel | 21q CN > 5 | |
Not reported | 12q? to 12qtel | 21q CN > 5 | |||
Not reported | 6ptel-6p? | Normal | |||
Not reported | 6ptel-6p? | 21q CN > 5 | |||
Not reported | 6pter-6p? | 21 CN 3–4 | |||
Not reported | 6pter-6p? | 21 CN 3–4 | |||
Lundin 2016 [16] | 181 | 28 | 6ptel-6p22.2 | Normal | |
31 | 6ptel-6p22.1 | Unknown | |||
19 | 12q14.1-12qtel | +21,+21 | |||
Mullighan 2007 [20] | 192 | TCF3-PBX1 #3 | 6ptel-6p22.1 | Unknown | |
ETV6-RUNX1 #10 | 6ptel-6p21.1 | Unknown | |||
HD 47-50 #22 | 6ptel-6p22.1 | Unknown | |||
HD > 50 #34 | 6ptel-6p22.1 | Unknown | |||
Pseudodiploid #8 | 6p12.3-6p21.31 | Unknown | |||
Paulsson 2010 [6] | 116 | HD > 50 (All) | |||
Ninomya 2012 [19] | 21 | AA214 | 6-p12.1-6pcen | Normal | |
AA217 | 6p21.33-6p25.3 | Normal |
