Table 3 Chromosome 21 CN status in cases of B-ALL with abnormalities of SH2B3 reported in the literature

Study	Diagnosis	patient ID	abnormality	Sub-type	chr 21 CN status
Roberts 2014 [28]	B-ALL	SJBALL021786	p.L224fs	Ph-like	+21
	B-ALL	SJBALL021415	Deletion	Ph-like	+21
	B-ALL	SJBALL020013	Deletion	Ph-like	iAMP21^a
	B-ALL	SJHYPO018	p.V402M	Ph-like	+21
	B-ALL	SJBALL020984	p.L347fs	Ph-like	iAMP21^a
	B-ALL	SJBALL239	N/A	Ph-like	iAMP21^a
	B-ALL	SJBALL021720	p.A98D	Ph-like	iAMP21^a
	B-ALL	SJBALL021058	p.S245_E3splice	Ph-like	iAMP21^a
	B-ALL	SJBALL021373	p.R398fs	Ph-like	iAMP21^a
Perez-Garcia 2013 [27]	B-ALL	NA	pD231fs	NA	Normal
Perez-Garcia 2013 [27]	B-ALL	NA	pQ427fs	NA	NA
Lindqvist 2016 [30]	B-ALL	(B) ALL-128	p.L188P/p.Q191fs/ p.S192R/p.193_194del	Other	NA
Lindqvist 2016 [30]	B-ALL	(B) ALL-109	p.G312V	t(12;21)	NA
Olsson 2015 [29]	B-ALL	2	Deletion	Other	NA
	B-ALL	5	Deletion	iAMP21	iAMP21
	B-ALL	20	fs^b	HeH	+21
	B-ALL	N/A	p.S213R	NA	NA
	B-ALL	N/A	p.E78K	NA	NA
	B-ALL	N/A	p.R175W	NA	NA
	B-ALL	N/A	p.R397G	NA	NA
Ivanov Ofverholm 2016 [41]	B-ALL	KSALL12	Deletion	iAMP21	iAMP21
	B-ALL	KSALL20	Deletion	iAMP21	iAMP21
	B-ALL	KSALL44	Deletion	iAMP21	iAMP21
Reshmi 2017 [31]	B-ALL	PAVJMN	Missense^b	Ph-like	iAMP21^a
	B-ALL	PAUZPC	Deletion	Ph-like	iAMP21^a
	B-ALL	PAVUJK	Deletion	Ph-like	iAMP21^a
	B-ALL	PAUXDJ	fs^b	Ph-like	iAMP21^a
	B-ALL	PAWBPX	Deletion	Ph-like	iAMP21^a
	B-ALL	PAVGVK	Deletion	Ph-like	iAMP21^a
	B-ALL	PAVMFF	Deletion	Ph-like	+21, +21, +21^a
Russell 2017 [32]	B-ALL	11706	fs^b	iAMP21	iAMP21

^aChromosome CN status not disclosed on publication, personal communication from M. Devidas on behalf of the Childrens Oncology Group USA
^bsequence change not presented

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