Fig. 3
From: A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes
Gene dosage effect and DNA methylation pattern on 7q and 1q regions of dic(1;7). a Chromosome view of regions significantly enriched in genes differentially expressed using PGE (Positional Gene Enrichment) on 7q (left). Percentage of differentially expressed gene (DEG) distribution within down- and up-regulated genes in dic(1;7) compared to controls (up-right) and to therapy-related myeloid neoplasms (t-MNs; bottom right). Compared to controls, 117/120 of 7q DEGs were downregulated in dic(1;7), while compared to t-MNs, 118/123 7q DEGs were downregulated. b Chromosome view of regions significantly enriched in genes differentially expressed using PGE on 1q (left). Percentage of DEG distribution within down- and up-regulated genes in dic(1;7) compared to controls (up-right) and to t-MNs (bottom right). The signature of dic(1;7) contained 90 up- and 108 (54.5%) down-regulated genes on 1q compared to controls; 52 up- and 105 (66.8%) down-regulated genes on 1q compared to t-MNs. c Differentially methylated region (DMR) distribution along chromosome 1q involved in the translocation. Dicentric cases showed hypermethylation of DMRs on 1q compared to both controls (left) and t-MN (middle). By contrast, t-MNs showed a prevalent hypomethylated pattern on 1q (right)
