Fig. 5
From: A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes
Summary of annotation analysis. a Table summarizing the distribution of annotated differentially methylated regions (DMRs) on genomic regions for each group. We used Methylkit package on R to annotate previously identified DMRs on Methylsig to hg19. Statistical results for binomial enrichment/depletion test were conduct on R. For all tests, we used 95% confidence interval and percentage of background annotation for each category (promoters, exons, introns, intergenic) as true probability of success. b Pie charts illustrate DMRs annotated to promoter (red), exonic (green), intronic (blue) and intergenic regions (purple) in dic(1;7) (DIC) vs. control (CTL; left) and vs. therapy-related myeloid neoplasm (t-MN; right). As background, we used total identified DMRs without filters (top left). c Distribution of hypo- and hypermethylated DMRs on promoter regions for each comparison (top) and relative number of hypo- and hyper-promoter DMRs for each group (bottom). d Venn diagram showed the overlap between genes annotated to promoter DMRs and all differentially expressed genes (DEGs) identified on RNA-sequencing (RNA-seq) analysis in DIC vs. CTL (i) and vs. t-MN (ii)
