Fig. 6
From: A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes
Summary of enhancers analysis. a Pie chart illustrates differentially methylated region (DMR) enrichment on enhancer regions. Red indicates feat1, enhancers; and light blue indicates others, non-enhancers. Compared with controls (CTL), dic(1;7) (DIC) DMRs showed an enrichment on enhancers with p value < 2.2e−16 (left), compared with therapy-related myeloid neoplasms (t-MNs) that showed an enrichment on enhancers with p value of 6.617e−06 (middle) and t-MNs compared with controls that showed an enrichment on enhancers with p = 0.046 (right). For statistical analysis, we used binomial test with 95% confidence interval and percentage of background annotation as true probability of success. b Venn diagrams illustrate the overlap between hypermethylated enhancer target genes and downregulated signature on DIC/CTL (left) and DIC/t-MN (right) groups
