Table 4a Correlation between response according to KIT D816V expressed allele burden and response to midostaurin in vitro

From: Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis

 

Response to midostaurin in vitrob,c

All

No

Yes

Response according to KIT D816V EAB in PBa

No

6

1

7

Yes

0

5

5

 

All

6

6

12

  1. EAB expressed allele burden, PB peripheral blood
  2. aResponse defined as reduction of the KIT D816V EAB in PB ≥ 25% after six months [20]
  3. bResponse defined as reduction of KIT D816V positive colonies ≥ 50% after two weeks in vitro
  4. cIn three cases, in vivo data was used for statistical analysis because in vitro data was not available
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