Fig. 5 | Leukemia

Fig. 5

From: The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Fig. 5

BAY 2402234 induces transcriptional changes linked to differentiation, apoptosis, and MYC repression. GSEA analysis of RNASeq read counts from MOLM-13 xenograft tumors harvested 24 h after a single treatment with 5 mg/kg BAY 2402234 or vehicle control. Enrichment plots are shown for signatures of (a) HOXA9 knockdown in MOLM-14 cells, (b) apoptosis-associated genes, and (c) MYC target genes

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