Fig. 1 | Leukemia

Fig. 1

From: Chronic myeloid leukemia stem cells

Fig. 1

Structural and functional features of the bone marrow microenvironment. Before TKI-therapy downregulation of CXCR4 by P210BCRABL1 and increased expression of CD26 on CML LSCs causes them to exit the bone marrow and enter the blood. TKI-therapy reverses these effects causing CML LSCs are home to the bone marrow promoting their persistence

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