Fig. 3 | Leukemia

Fig. 3

From: Chronic myeloid leukemia stem cells

Fig. 3

Autophagy in CML. The interaction of P210BCRABL1 with PI3K-AKT inhibits autophagy. Contrariwise, TKIs inhibit kinase activity of P210BCRABL1 enhancing autophagy. These autophagy effects may kill CML progenitor cells but may preserve CML LSCs

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